Association of СОМТ, DRD2/ANKK1, MTHFR, MIR 137, DNMT3B polymorphisms with the clinical features of schizophrenia patients in acute stage and remission

Updated view of genetic features schizophrenia based on rare SNPs/CNVs with a huge influence disease and common SNPs small effect each allele is presented. Altogether these factors are acting to create neuropathophysiological disturbances observed in schizophrenia. Association five polymorphisms MIR137 rs1625579, DRD2/ANKK1 rs1800497, MTHFR rs1801133, DNMT3B rs2424913, СОМТ rs4680 the risk Belarusian population, level symptoms patients assessed by PANSS acute stage remission, cognitive impairments, treatment trajectory during antipsychotic were analyzed. The A/A-genotype (р = 0.008) С/С-genotype rs1801133 0.02) associated among Belarusians. T-allele factor positive 0.02). Combining C/C-genotype (DNMT3B rs2424913) G-allele (COMT rs4680) significant difference negative between men women. polymorphism < 0.05) combination + rs1800497 0.005) as well rs2424913 0.006) related parameters measured WCST Stroop test respectively. Schizophrenia who carriers rs1625579 demonstrated more favorable symptom comparison Т/Тhomozygotes (F 2.2, p 0.03). 0.03) general psychopathological 4.3, 0.0001) different women under treatment. These differences minor amount alleles polymorphic sites.